Lethal Variance Detection (Grade A)Security-tested data-ai skill for Claude AI. Grade A. Detect drugs and substances with extreme safety variance across species where a safe dose in one species is lethal in another. CRITICAL SAFETY SKI

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Reviewed by Daniel Nikulshyn·Updated July 2026

Overview

Lethal Variance Detection is a critical safety skill for identifying drugs and substances with extreme safety variance across species. It detects substances that can be safe in one species but lethal in another, even at similar doses. This skill is essential for preventing iatrogenic animal death caused by well-documented, dramatic differences in drug safety profiles across species. It should be used automatically before providing any drug dosing information, especially when prescribing or recommending drugs for different species, or when considering off-label use. The skill provides specific guidance on hazardous substances, such as acetaminophen in cats, permethrin in cats, and ivermectin in certain dog breeds.

Key features

Detects lethal variance in drug safety across species
Provides specific guidance on hazardous substances
Flags high-risk drugs for certain species
Recommends genetic testing for high-risk breeds

Pricing

Model: Free
Category: Skills
Rating: No reviews yet

Use cases

Drug Prescription for Multiple Species

Use the Lethal Variance Detection skill when prescribing or recommending drugs for different species, such as dogs and cats, to ensure safe dosing and prevent lethal reactions.

Off-Label Drug Use

Use the skill when considering off-label use of a drug in a different species to identify potential safety risks and prevent adverse reactions.

Multi-Species Household

Use the skill when dealing with a multi-species household, such as a dog and cat in the same home, to ensure that drugs safe for one species are not lethal to another.

Pros & Cons

Pros

Prevents iatrogenic animal death
Identifies critical safety risks across species
Provides specific guidance for hazardous substances

Cons

Requires up-to-date knowledge of drug safety profiles across species
May not cover all possible drug interactions or safety risks

Reviews

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Q&A

What are the limitations of Lethal Variance Detection?

It requires up-to-date knowledge of drug safety profiles across species and may not cover all possible drug interactions or safety risks.

Asked by Paulo Cardoso · Oct 31, 2025

When should this skill be used?

This skill should be used automatically before providing any drug dosing information, especially when prescribing or recommending drugs for different species, or when considering off-label use.

Asked by Fumiko Sato · Oct 16, 2025

What substances does it provide guidance on?

It provides specific guidance on hazardous substances such as acetaminophen in cats, permethrin in cats, and ivermectin in certain dog breeds.

Asked by Celia Ramirez · Oct 14, 2025

What is Lethal Variance Detection used for?

Lethal Variance Detection is used to identify drugs and substances with extreme safety variance across species, preventing iatrogenic animal death.

Asked by Uma Krishnan · Jul 4, 2025

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