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Comparative Medicine Search (Grade A)Security-tested data-ai skill for Claude AI. Grade A. Search for relevant human medical research that may inform veterinary clinical decisions when veterinary-specific evidence is lacking. Use when no

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Daniel NikulshynReviewed by Daniel Nikulshyn·Updated June 2026

Overview

This skill, Comparative Medicine Search, is used to find relevant human medical research that can inform veterinary clinical decisions when veterinary-specific evidence is lacking. It structures the process of searching for human evidence, assessing its applicability to veterinary patients, and clearly communicating the limitations of cross-species extrapolation. It can be applied in various scenarios such as when no species-specific RCTs or guidelines exist, or when a novel treatment being considered in animals has an evidence base in human medicine. The skill first searches for species-specific veterinary evidence, and if insufficient, it searches human PubMed for the clinical topic. It assesses the biological plausibility of cross-species application by considering factors such as pathophysiology, drug targets, and pharmacokinetic parameters. Finally, it grades the comparative evidence as Level IV and clearly labels all cross-species extrapolations in the output. This skill has been successful in various medical areas, including cardiac disease, oncology, pain management, and diabetes, but it also has limitations, such as when it fails in drug metabolism due to species-specific differences, or in behavioral medicine due to differences in cognitive and behavioral processes across species. When using comparative evidence, the skill includes a framing statement to highlight the limitations of the evidence and the need for further validation studies. Overall, the Comparative Medicine Search skill provides a valuable tool for veterinarians and researchers to inform their clinical decisions when veterinary-specific evidence is lacking.

Key features

  • Searches for species-specific veterinary evidence
  • Searches human PubMed for the clinical topic
  • Assesses biological plausibility of cross-species application
  • Grades the comparative evidence as Level IV
  • Clearly labels all cross-species extrapolations in the output

Pricing

Model
Free
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Skills
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Use cases

Cardiac disease

Many canine cardiac drugs were developed from human cardiology research, and have been successfully used in animals.

Oncology

Cancer biology is highly conserved, and chemotherapy protocols in veterinary oncology derive from human oncology.

Pain management

Opioid, NSAID, and gabapentin use in animals draws heavily on human pain research and has been found to be effective.

Diabetes

Insulin therapy principles in animals translate from human medicine, but the disease pathophysiology differs between species.

Pros & Cons

Pros

  • Provides a structured approach to finding relevant human medical research
  • Assesses the applicability of human evidence to veterinary patients
  • Communicates the limitations of cross-species extrapolation
  • Successful in various medical areas such as cardiac disease, oncology, and pain management
  • Provides a clear and concise output format

Cons

  • Limited in drug metabolism due to species-specific differences
  • Ineffective in behavioral medicine due to differences in cognitive and behavioral processes across species
  • Cross-species extrapolation is inherently uncertain
  • Human dosing is not directly applicable to animals without species-specific pharmacokinetic data

Battle record

Across 1 battle in the Pantheon.

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Q&A

What is OpenVet?

OpenVet is the AI hospital for every animal on earth, a multi-agentic platform that puts the depth of a full hospital behind every veterinary decision, across 200+ species.

Asked by Yaw Owusu · May 21, 2026

How does OpenVet work?

Veterinarians ask any clinical question and OpenVet returns structured, evidence-based answers with citations from canonical veterinary literature. Drug doses come from verified reference data, not generated text. Every response includes confidence indicators and stated assumptions.

Asked by Grace Okafor · May 2, 2026

What species does OpenVet cover?

OpenVet covers all animal species. Its clinical reasoning engine is species-agnostic by design, spanning companion animals (dogs, cats), production animals (cattle, swine, poultry), equine, small ruminants, exotic species (birds, reptiles, small mammals), and wildlife.

Asked by Urszula Kowalczyk · Apr 28, 2026

Is OpenVet safe for clinical use?

OpenVet publishes the Veterinary AI Safety Charter, a public commitment to safety, transparency, and clinician oversight. Drug doses are calculated from hardcoded reference data, never AI-generated. Every answer includes citations and confidence indicators. OpenVet extends clinical judgment; it never replaces it.

Asked by Zara Ahmed · Apr 24, 2026

Who founded OpenVet?

OpenVet was founded in January 2025 by Adam Sager (CEO) and Andrew Heller (COO). Dr. Natalie Marks serves as Chief Veterinary Officer. The company is headquartered in Miami, FL.

Asked by Rasheed Osman · Mar 30, 2026

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